Journal Club
Molecular Medicine
Welcome to our journal club of top scientific papers with medical impact
Currently, the Journal Club Molecular Medicine does not take place.
The last JCMM was:
Tuesday, 8 May 2007 at 6.00pm, seminar room 6 at the MTZ
Waldemar Kanczkowski from Professor Bornstein's group will present the following paper:
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.
Tian J. et al., Nat. Immunol. May 2007; 8(5): 487-96.
download the article
Of course! We welcome everbody - students, PhDs, postdocs, group leaders, and doctors. Come along and participate in the discussion. Or even better, present a paper yourself.
Which papers for the JCMM?
The JCMM is here to critically discuss top scientific papers with medical impact. To assess whether a paper is of top quality the publishing journal is a first but not a fully reliable indicator; Cell*, JCB, NEJM, Nature*, PLoS, and Science belong to the 1st tier of journals (*including subjournals). The impact factor can also be used to probe a journal's overall quality - see links below - but use with care. In "Faculty of 1000" researcher recommend papers. Especially, its hidden jewels section is a great place to hunt for papers which, because of lack of personal connections or because of unfashionable topic, didn't make it into the top journals.
- Look out for papers with a clear hypothesis and a stringent flow of molecular experiments that support or confute each point, before moving to the next. Avoid descriptive papers of phenomena without molecular explanation.
- The paper should also be very recent, i.e. not more than 1 year old. The more recent the better.
- It should be truly a breakthrough in molecular medicine: a novel pathway, a novel amazing gene, a novel therapy.
- It should be exciting; something you wish to tell your friends and colleagues over lunch or a beer.
- It may be controversial - all the better.
Web of knowledge by Thomson (makers of impact factor) - easy to navigate
Faculty of 1000 - scientists recommend papers; see esp. hidden jewels
Where is the MTZ?
The MTZ is located between Fiedlerstraße and
Blasewitzer
Straße (see map). The postal address is
Fiedlerstr. 42.
Go into the main hall and up the stairs. We are
usually in seminar room number 6.
Contact
Any questions concerning the journal club Katja Pfriem will answer. You can reach her by phone (+49 (0)351 458.6612) or by email (katja.pfriem{at}tu-dresden.de). If you would like to present a paper or if you have questions, she is the person to talk to.
Past papers discussed in the journal club
| 08.05.07 | Waldemar Kanczkowski | Toll-like receptor 9-dependant activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE. |
| 27.03.07 | Francisco Pan-Montojo | Reversal of Neurological Defects in a Mouse Model of Rett Syndrome. |
| 13.03.07 | Christin Süß | Beta-cell ABCA1 influences insulin secretion, glucose
homeostasis and response to thiazolidinedione treatment. |
| 13.02.07 | Fernando Fierro | Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. |
| 16.01.07 | Sina Koch | Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. |
| 05.12.06 | Anna Ivanova | NR4A orphan nuclear receptors are transcriptional
regulators of hepatic glucose metabolism. |
| 24.10.06 | Slava Stamova | T cell- and B cell-independent adaptive immunity mediated by natural killer cells. |
| 26.09.06 | Ruiyu Zhu | The identification of an internal ribosomal entry site in the 5 '-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage. |
| 13.06.06 | Sina Koch | Hematopoiesis Controlled by Distinct TIF1gamma and Smad4 Branches of the TGFbeta Pathway. |
| 30.05.06 | Fernando Ugarte | Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior. |
| 16.05.06 | Jakob Suckale | Virulence and competitive ability in genetically diverse malaria infections. |
| 02.05.06 | Fernando Fierro | A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. |
| 18.04.06 | Christin Süß | Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas |
| 04.04.06 | Alessio Attardo | 1) Intraneuronal Abeta causes the onset of early
Alzheimer's disease-related cognitive deficits in transgenic mice 2) M1 receptors play a central role in modulating AD-like pathology in transgenic mice |
| 20.03.06 | Anne K. Meyer | Signals from the sympathetic nervous system regulate
hematopoietic stem cell egress from bone marrow |
| 07.03.06 | Susanne Mende | Novel role of p53 in maintaining mitochondrial genetic
stability through interaction with DNA Pol gamma |
| 21.02.06 | Serap Günes | Restoring function in exhausted CD8 T cells during chronic viral infection. |
| 10.01.06 | Magalie Lebreton | Trans-arachidonic acids generated during nitrative stress induce a thrombospondin-1–dependent microvascular degeneration |
| 13.12.05 | Susanne Mende | Dopamine covalently modifies and functionally inactivates parkin |
| 15.11.05 | Sina Koch | Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance |
| 01.11.05 | Laura Buffa | Coincident scrapie infection and nephritis lead to urinary prion excretion |
| 18.10.05 | Fernando Fierro | Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons |
| 04.10.05 | Ana Cunha | mtDNA mutations increase tumorigenicity in prostate cancer. |
| 28.06.05 | Magalie Lebreton | Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia. |
| 14.06.05 | Christin Süß | Differentiation of Insulin-Producing Cells from Human Neural Progenitor Cells. |
| 24.05.05 | Anne K. Meyer | The KIF3 motor transports N-cadherin and organizes the developing neuroepithelium. |
| 03.05.05 | Serap Günes | Inhibition of Malignant Glioma Cell Growth by a Survivin Mutant Retrovirus |
| 26.04.05 | Alessio Artado | Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals |
| 12.04.05 | Gaspare Benenati | Mouse Development and Cell Proliferation in the Absence of D-Cyclins |
| 15.02.05 | Fernando Fierro | Postnatal isl1(+) cardioblasts enter fully differentiated cardiomyocyte lineages. Nature. 2005 |
| 08.02.05 | Sina Koch | Shisa Promotes Head Formation through the Inhibition of Receptor Protein Maturation for the Caudalizing Factors, Wnt and FGF. Cell 2005 |
| 25.01.05 | Fuat Y. Aksoy | Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells. Nat Biotechnol. 2005 |
| 07.12.04 | Sina Koch | Regulation of the cyclin A1 protein is associated with its differential subcellular localization in hematopoietic and leukemic cells. Oncogene 2004 |
| 30.11.04 | Nicola Bauer | Joseph et al. LXR-dependent gene expression is important for macrophage survival and the innate immune response. Cell 2004 |
| 24.11.04 | Ana Cunha | Karhadkar et al. Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature 2004 |
| 19.10.04 | Bartosz Balana | Sato et al. Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nature Medicine 2004 |
| 05.10.04 | Michael Kasper | Hashimoto et al. Bone marrow-derived progenitor cells in pulmonary fibrosis. |
| 20.09.04 | Serap Gunes | Saffran et al. Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts. |
| 28.06.04 | Jakob Suckale | Brinkmann et al. Neutrophil extracellular traps kill bacteria. |
| 14.06.04 | Marek Drab | Acevedo et al. A new role for Nogo as a regulator of vascular remodeling. |
| 17.05.04 | Susanne Mende | Lustbader et al. ABAD Directly Links Ab to Mitochondrial Toxicity in Alzheimer's Disease. |