solimena group

Michele Solimena - short CV


Education:

1974-1979: Lyceum Berchet, Milano, Italy (Maturita Classica)
1979-1986: University of Milano, School of Medicine, Italy (M.D.)
1989-1992: University of Milano, School of Medicine, Italy (Ph.D. in Pharmacology and Toxicology)

Career:

1986 - 1988: Postdoctoral Fellow, Dept. of Pharmacology University of Milano School of Medicine, Milano, Italy
1988 - 12/1993: Postdoctoral Fellow, Dept. of Cell Biology, Yale University School of Medicine, New Haven, CT, USA
01/1994 - 12/1999: Assistant Professor, Dept. Internal Medicine, Section of Endocrinology, Yale University School of Medicine
01/2000 - 09/2001: Associate Professor, Dept. Internal Medicine and Cell Biology, Yale University School of Medicine
10/2001-12/2002: Group Leader, Max Planck Institute of Molecular Biology and Genetics, Dresden
since 2003: C3-Professor of Molecular Diabetology, Medical School, TU Dresden, Germany
since 2007: Fellow of the MaxPlanck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
since 2009: W3-Professor of Molecular Diabetology, Medical School, TU Dresden, Germany
since 07/2009: Speaker Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD)


Honors and Awards:

2007 - 2012: Max Planck Fellow, Max Planck Society
2001 - 2005: "Wolfgang Paul" Award, Alexander von Humboldt Foundation
1994 - 1997: Juvenile Diabetes Foundation Career Development Award
1992 - 1994: Juvenile Diabetes Foundation Postdoctoral Fellowship
1989 - 1991: "Sydney Blakmer" Muscular Dystrophy Association Fellowship
1988 - 1989: Giuseppe Levi's Foundation-Lincei's National Academy
1988: Upjohn Prize -Italian Society for Pharmacology
1986 - 1987: Trabucchi Fellowship -Univ. of Milano

Publications since 2000:

 1) Butler MH, Hayashi A, Ohkoshi N, Villman C, Beckerle C-M, Feng G, De Camilli P, Solimena M. 2000. Autoimmunity to gephyrin in stiff-man syndrome. Neuron 26: 307-312.
 2) Ort T, Maksimova E, Dirkx R, Kachinsky A, Berghs S, Froehner S, Solimena M. 2000. The receptor tyrosine phosphatase like-protein ICA512 binds the PDZ domains of β2-syntrophin and nNOS in pancreatic β-cells. Eur. J. Cell Biol. 79: 621-630.
 3) Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel J-H, Zhang J-P, Philbrick W, Slepnev V, Ort T, Solimena M. 2000. βIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous system. J Cell Biol 27: 985-1002.
 4) Solimena M and De Camilli, P. 2000. Synaptic autoimmunity and the Salk factor. Neuron 28: 309-310.
 5) Berghs S, Ferracci F, Maksimova E, Gleason S, Leszczynski N, Butler M, De Camilli P, Solimena M.  2001. Autoimmunity against β-IV-spectrin in paraneoplastic motor neuron syndrome. PNAS USA 98: 6945-6950.
 6) Meinck H-M, Maile S, Faber L, Morgenthaler N, Seissler J, Butler M, Solimena M, DeCamilli P, Scherbaum WA. 2001. Antibodies against glutamic acid decarboxylase (GAD)- prevalence in neurological diseases. J. Neurol. Neurosurg. Psych 71:100-103.
 7) Ort T, Voronov S, Guo J, Zawalich K, Froehner S, Zawalich W, Solimena M. 2001. Dephosphorylation of  β2-syntrophin and Ca2+/calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. EMBO J 20: 4013-4023.
 8) Schmierer K, Grosse P, De Camilli P, Solimena M, Floyd S, Zschenderlein R. 2002. Paraneoplastic   stiff-person syndrome - no tumor progression over five years. Neurology 58: 148.
 9) Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, Solimena M. 2003. Islet Cell Autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. J Biol Chem 278: 26166-26173.
10) Solimena M and Gerdes H-H. 2003. Secretory granules: and the last shall be first.... Trends Cell Biol 13: 399-402.
11) Petzold GC, Marcucci M, Butler MH, van Landeghem FK, Einhaupl KM, Solimena M, Valdueza JM, De Camilli P. 2004. Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. Ann Neurol 55: 286-290.
12) Knoch KP, Bergert H, Borgonovo B, Saeger HD, Altkruger A, Verkade P, Solimena M. 2004. Polypyrimidine tract-binding protein promotes insulin secretory granule biogenesis. Nat Cell Biol 6: 207-214.
13) Yang Y, Lacas-Gervais S, Morest DK, Solimena M, Rasband MN. 2004. BetaIV spectrins are essential for membrane stability and the molecular organization of nodes of Ranvier. J Neurosci. 24: 7230-7240.
14) Lacas-Gervais S, Guo J, Strenzke N, Scarfone E, Kolpe M, Jahkel M, De Camilli P, Moser T, Rasband MN, Solimena M. 2004. BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial  segments. J Cell Biol 166: 983-990.
15) Trajkovski M, Mziaut H, Altkruger A, Ouwendijk J, Knoch KP, Muller S, Solimena M. 2004. Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in beta-cells. J Cell Biol 167: 1063-1074.
16) Murinson BB, Butler M, Marfurt K, Gleason S, De Camilli P, Solimena M. 2004. Markedly elevated GAD antibodies in SPS: effects of age and illness duration. Neurology 63: 2146-2148.
17) Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M, Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M. 2005. An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol 170: 607-618.
18) Bergert H, Knoch KP, Meisterfeld R, Jager M, Ouwendijk J, Kersting S, Saeger HD, Solimena M. 2005. Effect of oxygenated perfluorocarbons on isolated rat pancreatic islets in culture. Cell Transplant 14: 441-448.  
19) Knoch KP, Meisterfeld R, Kersting S, Bergert H, Altkruger A, Wegbrod C, Jager M, Saeger HD, Solimena M. 2006. cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells. Cell Metab 3: 123-134.
20) Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkruger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Muller S, Solimena M. 2006. Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Nat Cell Biol 8: 435-445.
21) Trajkovski M, Mziaut H, Schwarz PE, Solimena M. 2006. Genes of type 2 diabetes in Beta cells. Endocrinol Metab Clin North Am 35: 357-369.
22) Borgonovo B, Ouwendijk J, Solimena M. 2006. Biogenesis of secretory granules. Curr Opin Cell Bio 18: 365-370.
23) Ehninger A, Mziaut H, Solimena M. 2007. Emerging role of SUMO in pacreatic β-cells. Horm Metab Res 39: 658-64.
24) Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. 2008. ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. Eur J Cell Biol 87: 197-209.
25)  Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M. 2008. ICA512 signaling enhances panreatic β-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci USA 105: 674-9.
26) Suckale J, Solimena M. Pancreas islets in metabolic signaling – focus on the β-cell. 2008. Frontiers in Bioscience.
27) Trajkovski M, Mziaut H, Schubert S, Kalaidzidis Y, Altkrüger A, Solimena M. 2008. Regulation of insulin granule turnover in pancreatic beta-cells by cleaved ICA512. J Biol Chem. 2008.             Nov 28;283(48):33719-29

28) Süss C, Czupalla C, Winter C, Pursche T, Knoch KP, Schroeder M, Hoflack B, Solimena M. Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells. Mol Cell Proteomics. 2009 Mar;8(3):393-408.
29) Liu Y, Mziaut H, Ivanova A, Solimena M. beta-Cells at the crossroads: choosing between insulin granule production and proliferation. Diabetes Obes Metab. 2009 Nov;11 Suppl 4:54-64.
29) Ries J, Bayer M, Csúcs G, Dirkx R, Solimena M, Ewers H, Schwille P. Automated suppression of sample-related artifacts in Fluorescence Correlation Spectroscopy. Opt Express. 2010 May 24;18(11):11073-82.
30) Suckale J, Solimena M. The insulin secretory granule as a signaling hub. Trends Endocrinol Metab. 2010 Oct;21(10):599-609.
31) Solimena M, Speier S. Insulin release: shedding light on a complex matter. Cell Metab. 2010 Jul 4;12(1):5-6.
32) Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M. β2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules. PLoS One. 2010 Sep 23;5(9):e12929.
33) Liu Y, Suckale J, Masjkur J, Magro MG, Steffen A, Anastassiadis K, Solimena M. Tamoxifen-independent recombination in the RIP-CreER mouse. PLoS One. 2010 Oct 22;5(10):e13533.
34) Ehehalt F, Knoch K, Erdmann K, Krautz C, Jäger M, Steffen A, Wegbrod C, Meisterfeld R, Kersting S, Bergert H, Kuhlisch E, Bornstein S, Bonifacio E, Saeger HD, Solimena M. Impaired insulin turnover in islets from type 2 diabetic patients. Islets. 2010 Jan-Feb;2(1):30-6.
35) Geis C, Weishaupt A, Grünewald B, Wultsch T, Reif A, Gerlach M, Dirkx R, Solimena M, Perani D, Heckmann M, Toyka KV, Folli F, Sommer C. Human stiff-person syndrome IgG induces anxious behavior in rats. PLoS One. 2011 Feb 8;6(2):e16775.
36) Suckale J, Wendling O, Masjkur J, Jäger M, Münster C, Anastassiadis K, Stewart AF, Solimena M. PTBP1 is required for embryonic development before gastrulation. PLoS One. 2011 Feb 17;6(2):e16992.
37) Steffen A, Ludwig B, Krautz C, Bornstein S, Solimena M. Functional assessment of automatically sorted pancreatic islets using large particle flow cytometry. Islets. 2011 Sep 1;3(5).
38) Bötticher G, Sturm D, Ehehalt F, Knoch KP, Kersting S, Grützmann R, Baretton GB, Solimena M, Saeger HD. Isolation of Human Islets from Partially Pancreatectomized Patients. J Vis Exp. 2011 Jul 30;(53).
39)
Primo ME, Jakoncic J, Noguera ME, Risso VA, Sosa L, Sica MP, Solimena M, Poskus E, Ermácora MR. Protein-Protein Interactions in Crystals of the Human Receptor-Type Protein Tyrosine Phosphatase ICA512 Ectodomain. PLoS One. 2011;6(9):e24191.
40) Fava E, Dehghany J, Ouwendijk J, Müller A, Niederlein A, Verkade P, Meyer-Hermann M, Solimena M. Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling. Diabetologia. 2012 Apr;55(4):1013-23. Epub 2012 Jan 18
41) Bonner SM, Pietropaolo SL, Fan Y, Chang Y, Sethupathy P, Morran MP, Beems M, Giannoukakis N, Trucco G, Palumbo MO, Solimena M, Pugliese A, Polychronakos C, Trucco M, Pietropaolo M. Sequence variation in the promoter of the Ica1 gene, which encodes a protein implicated in type 1 diabetes, causes the transcription factor AIRE to increase its binding and downregulate expression. J Biol Chem. 2012 Mar 24. [Epub ahead of print]

Contact details:

michele.solimena {at} tu-dresden.de
+49 (0)3 51 79 63 66 11