solimena group
Michele Solimena - short CV
Education:
1974-1979: Lyceum Berchet, Milano, Italy (Maturita Classica)1979-1986: University of Milano, School of Medicine, Italy (M.D.)
1989-1992: University of Milano, School of Medicine, Italy (Ph.D. in Pharmacology and Toxicology)
Career:
1986 - 1988: Postdoctoral Fellow, Dept. of Pharmacology University of Milano School of Medicine, Milano, Italy1988 - 12/1993: Postdoctoral Fellow, Dept. of Cell Biology, Yale University School of Medicine, New Haven, CT, USA
01/1994 - 12/1999: Assistant Professor, Dept. Internal Medicine, Section of Endocrinology, Yale University School of Medicine
01/2000 - 09/2001: Associate Professor, Dept. Internal Medicine and Cell Biology, Yale University School of Medicine
10/2001-12/2002: Group Leader, Max Planck Institute of Molecular Biology and Genetics, Dresden
From 2003: Professor of Experimental Diabetology, Medical School, TU Dresden, Germany
From 2007: Fellow of the MaxPlanck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Honors and Awards:
2007 - 2012: Max Planck Fellow, Max Planck Society2001 - 2005: "Wolfgang Paul" Award, Alexander von Humboldt Foundation
1994 - 1997: Juvenile Diabetes Foundation Career Development Award
1992 - 1994: Juvenile Diabetes Foundation Postdoctoral Fellowship
1989 - 1991: "Sydney Blakmer" Muscular Dystrophy Association Fellowship
1988 - 1989: Giuseppe Levi's Foundation-Lincei's National Academy
1988: Upjohn Prize -Italian Society for Pharmacology
1986 - 1987: Trabucchi Fellowship -Univ. of Milano
Publications since 2000:
1) Butler MH, Hayashi A, Ohkoshi N, Villman C, Beckerle C-M, Feng G, De Camilli P, Solimena M. 2000. Autoimmunity togephyrin in stiff-man syndrome. Neuron 26: 307-312.
2) Ort T, Maksimova E, Dirkx R, Kachinsky A, Berghs S, Froehner S, Solimena M. 2000. The receptor tyrosine phosphatase
like-protein ICA512 binds the PDZ domains of β2-syntrophin and nNOS in pancreatic β-cells. Eur. J. Cell Biol. 79: 621-630.
3) Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel J-H, Zhang J-P, Philbrick W, Slepnev V, Ort T, Solimena M.
2000. βIV spectrin, a new spectrin localized at axon initial segments and nodes of Ranvier in the central and peripheral nervous
system. J Cell Biol 27: 985-1002.
4) Solimena M and De Camilli, P. 2000. Synaptic autoimmunity and the Salk factor. Neuron 28: 309-310.
5) Berghs S, Ferracci F, Maksimova E, Gleason S, Leszczynski N, Butler M, De Camilli P, Solimena M. 2001. Autoimmunity
against β-IV-spectrin in paraneoplastic motor neuron syndrome. PNAS USA 98: 6945-6950.
6) Meinck H-M, Maile S, Faber L, Morgenthaler N, Seissler J, Butler M, Solimena M, DeCamilli P, Scherbaum WA. 2001.
Antibodies against glutamic acid decarboxylase (GAD)- prevalence in neurological diseases. J. Neurol. Neurosurg. Psych 71:100-103.
7) Ort T, Voronov S, Guo J, Zawalich K, Froehner S, Zawalich W, Solimena M. 2001. Dephosphorylation of β2-syntrophin and
Ca2+/calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. EMBO J 20: 4013-4023.
8) Schmierer K, Grosse P, De Camilli P, Solimena M, Floyd S, Zschenderlein R. 2002. Paraneoplastic stiff-person syndrome - no
tumor progression over five years. Neurology 58: 148.
9) Spitzenberger F, Pietropaolo S, Verkade P, Habermann B, Lacas-Gervais S, Mziaut H, Pietropaolo M, Solimena M. 2003. Islet
Cell Autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells. J Biol Chem
278: 26166-26173.
10) Solimena M and Gerdes H-H. 2003. Secretory granules: and the last shall be first.... Trends Cell Biol 13: 399-402.
11) Petzold GC, Marcucci M, Butler MH, van Landeghem FK, Einhaupl KM, Solimena M, Valdueza JM, De Camilli P.
2004. Rhabdomyolysis and paraneoplastic stiff-man syndrome with amphiphysin autoimmunity. Ann Neurol 55: 286-290.
12) Knoch KP, Bergert H, Borgonovo B, Saeger HD, Altkruger A, Verkade P, Solimena M. 2004. Polypyrimidine tract-binding
protein promotes insulin secretory granule biogenesis. Nat Cell Biol 6: 207-214.
13) Yang Y, Lacas-Gervais S, Morest DK, Solimena M, Rasband MN. 2004. BetaIV spectrins are essential for membrane stability and
the molecular organization of nodes of Ranvier. J Neurosci. 24: 7230-7240.
14) Lacas-Gervais S, Guo J, Strenzke N, Scarfone E, Kolpe M, Jahkel M, De Camilli P, Moser T, Rasband MN, Solimena M. 2004.
BetaIVSigma1 spectrin stabilizes the nodes of Ranvier and axon initial segments. J Cell Biol 166: 983-990.
15) Trajkovski M, Mziaut H, Altkruger A, Ouwendijk J, Knoch KP, Muller S, Solimena M. 2004. Nuclear translocation of an
ICA512 cytosolic fragment couples granule exocytosis and insulin expression in beta-cells. J Cell Biol 167: 1063-1074.
16) Murinson BB, Butler M, Marfurt K, Gleason S, De Camilli P, Solimena M. 2004. Markedly elevated GAD antibodies in SPS:
effects of age and illness duration. Neurology 63: 2146-2148.
17) Shin HW, Hayashi M, Christoforidis S, Lacas-Gervais S, Hoepfner S, Wenk MR, Modregger J, Uttenweiler-Joseph S, Wilm M,
Nystuen A, Frankel WN, Solimena M, De Camilli P, Zerial M. 2005. An enzymatic cascade of Rab5 effectors regulates
phosphoinositide turnover in the endocytic pathway. J Cell Biol 170: 607-618.
18) Bergert H, Knoch KP, Meisterfeld R, Jager M, Ouwendijk J, Kersting S, Saeger HD, Solimena M. 2005. Effect of oxygenated
perfluorocarbons on isolated rat pancreatic islets in culture. Cell Transplant 14: 441-448.
19) Knoch KP, Meisterfeld R, Kersting S, Bergert H, Altkruger A, Wegbrod C, Jager M, Saeger HD, Solimena M. 2006.
cAMP-dependent phosphorylation of PTB1 promotes the expression of insulin secretory granule proteins in beta cells. Cell Metab 3: 123-134.
20) Mziaut H, Trajkovski M, Kersting S, Ehninger A, Altkruger A, Lemaitre RP, Schmidt D, Saeger HD, Lee MS, Drechsel DN, Muller
S, Solimena M. 2006. Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5. Nat Cell Biol
8: 435-445.
21) Trajkovski M, Mziaut H, Schwarz PE, Solimena M. 2006. Genes of type 2 diabetes in Beta cells. Endocrinol Metab Clin North Am 35: 357-369.
22) Borgonovo B, Ouwendijk J, Solimena M. 2006. Biogenesis of secretory granules. Curr Opin Cell Bio18: 365-370.
23) Ehninger A, Mziaut H, Solimena M. 2007. Emerging role of SUMO in pacreatic β-cells. Horm Metab Res 39: 658-64.
24) Buffa L, Fuchs E, Pietropaolo M, Barr F, Solimena M. 2008. ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking
in insulinoma cells. Eur J Cell Biol 87: 197-209.
25) Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M. 2008.
ICA512 signaling enhances panreatic β-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci USA 105: 674-9.
26) Suckale J, Solimena M. Pancreas islets in metabolic signaling – focus on the β-cell. 2008. Frontiers in Bioscience.
Contact details:
michele.solimena {at} tu-dresden.de
+49 (0)351 458.6611