solimena group
Silvia Brambillasca
TITLE
ICA512 is an integral membrane protein enriched in insulin secretory granules of pancreatic beta cells. Previous studies in our laboratory have shown that the cytoplasmic domain of ICA512 is able to bind to the PDZ domain of beta2-syntrophin, which in turn is linked to the cortical actin meshwork via direct binding to utrophin. This complex may therefore theter insulin granules to the cortical actin cytoskeleton and regulate their trafficking and exocytosis.
Silvia’s project is focused on evaluating how the post-translational modifications occurring on ICA512 and beta2-syntrophin may modulate the interaction between the two and, as a consequence, the release of insulin granules.
Contact details:
silvia.brambillasca {at} tu-dresden.de
+49 (0)351 458.6613