solimena group

Teodora Bojic

PhD project Teodora

POST-TRANSCRIPTIONAL REGULATION OF INSULIN SECRETORY GRANULE BIOGENESIS

The regulated biosynthesis and release of insulin secretory granules (SGs) by the pancreatic β-cells is tightly controlled by both transcriptional and post-transcriptional mechanisms. Release of ready stores of SGs, as well as translational control of SG mRNAs allows for a rapid response to external stimuli, while transcriptional upregulation ensures the long-term replenishment of insulin SG components. My PhD project focuses on the involvement of RNA-binding proteins in the post-transcriptional regulation of insulin SG biogenesis. The overall goal of the project is to elucidate the aspects of these proteins’ roles specific to proper β-cell function, with an emphasis on the mechanisms by which they control translation and stability of their target SG mRNAs. A better understanding of these complex pathways is essential, and identification of the key players and mechanisms involved is a crucial step towards better understanding how their impaired function could lead to a major metabolic disease.

Contact details:

teodora.bojic {at} mailbox.tu-dresden.de
+49 (0)3 51 79 63 66 12